This study addresses these bioethical implications in the use of digital technologies to conduct mental health research, as noted by the Research Ethics Committee of the Ramón de la Fuente Muñiz National Institute of Psychiatry during the social distancing measures during the COVID-19 pandemic in Mexico. The increased use of digital tools abruptly transformed the manner in which studies were conducted, especially for those not familiar with this modality. The transition to these new digital technologies must include consideration of the bioethical implications of these strategies, and ethics committees must work with researchers to identify the best ways to safeguard the dignity, autonomy, and rights of participants.